Antiproliferative activity of different extracts from Daphne altaica Pall. on selected cancer cells Murat Kizaibek1,3, Marzia Daniar2, Lin Li2 and Halmurat Upur3*
1Traditional Kazakh Medicine Research Institute of Ili Kazakh Autonomous Prefecture, 835000 Yining, Xinjiang, P. R. China. 2Department of Biochemistry and Molecular Biology, College of Basic Medicine, Xinjiang Medical University, 830011 Urumqi, Xinjiang, P. R. China. 3Faculty of Traditional Uighur Medicine, Xinjiang Medical University, 830011 Urumqi, Xinjiang, P. R. China.
Abstract Daphne altaica Pall. (Thymelaeaceae) is a medicinal plant that has long been used to treat cancer and respiratory ailments in Traditional Kazakh Medicine. In order to systematically evaluate its potential anticancer activity, six extracts of different polarity, namely: aqueous, n-butanol, ethyl acetate, chloroform, petroleum ether and ethanol extracts were obtained from this plant and they were tested for their antiproliferative effects on four human cancer cell lines: esophageal squamous cell carcinoma, gastric carcinoma, hepatoma and cervical carcinoma cells. Results from the proliferation assay showed that all extracts, except for aqueous extract, exhibited a dose-dependent growth inhibitory effect on all cancer cell lines. Of these extracts, two fractions obtained from partitioning of ethanol extract, namely: chloroform extract and ethyl acetate extract, could be considered a potential source of anticancer compounds. Further studies are necessary for identification and chemical characterization of the active principles.
Conclusion The results of this study represent the first evidence that barks of D. altaica possess effective antiproliferative activities on human cancer cells. Future phytochemicalinvestigations on this medicinal plant should be encouraged.
Source : Journal of Medicinal Plants Research Vol. 5(15), pp. 3448-3452, 4 August, 2011 Link to Full Article