Triphala Composition of the drug Triphala (tri three, phala fruits) is a mixture of fruits of three plants: Terminalia chebula Retz. (Family Combretaceae), Terminalia bellerica (Gaertn.) Roxb. (Family Combretaceae), and Phyllanthus emblica (Linn) or Emblica officinalis (Gaertn.) (Euphorbiaceae) in powdered form in equal proportions (1:1:1).
Triphala, an Ayurvedic Rasayana Drug, Protects Mice Against Radiation-Induced Lethality by Free-Radical Scavenging GANESH CHANDRA JAGETIA, Ph.D., KRISHNA J. MALAGI, M.D. (Ayu), MANJESHWAR SHRINATH BALIGA, Ph.D., PONEMONE VENKATESH, M.SC. (Medical), and ROSI REDDY VERUVA, M.Pharm.
ABSTRACT The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 7–12 Gray (Gy) of -irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protection against both gastrointestinal and hemopoetic death. However, animals of both the TE irradiation and DDW irradiation groups did not survive up to 30 days post-irradiation beyond 11 Gy irradiation. The LD50/30 was found to be 8.6 Gy for the DDW irradiation group and 9.9 Gy for TE irradiation group. The administration of triphala resulted in an increase in the radiation tolerance by 1.4 Gy, and the dose reduction factor was found to be 1.15. To understand the mechanism of action of triphala, the free radical scavenging activity of the drug was evaluated. Triphala was found to scavenge •OH, O2• 2,2-azinobis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS)• and NO• radicals in a dose dependent manner.
Conclusion From our study it is clear that TE provided protection against radiation-induced sickness and mortality in mice and its free radical scavenging and antioxidant activities may be responsible for the observed radioprotection. Further experimental studies are planned to explore how TE may modulate the radiation-induced damage in radiation fractionation, for its utility in cancer treatment and its effect on cancer growth.
NB - Composition of the drug Triphala (tri three, phala fruits) is a mixture of fruits of three plants: Terminalia chebula Retz. (Family Combretaceae), Terminalia bellerica (Gaertn.) Roxb. (Family Combretaceae), and Phyllanthus emblica (Linn) or Emblica officinalis (Gaertn.) (Euphorbiaceae) in powdered form in equal proportions (1:1:1).
Source : THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE Volume 10, Number 6, 2004, pp. 971–978 Link to Full Article