Potent antitumor activity of Rubia cordifolia Parag R. Patel1*, Bhuvan P. Raval2, Hamsraj A. Karanth1, Vishal R. Patel3
1Parul Institute of Pharmacy, Limda, Vadodara, India 2K. J. College of Pharmacy,Vadasma-382708, North Gujarat, India Baroda college of Pharmacy, Limda, Vadodara, India
Abstract Background: Cancer is a leading cause of death. Rubia cordifolia is a traditional ayurvedic medicine being used as a remedy for various ailments.
Results: Dichloromethane fraction of Rubia cordifolia extract exhibited potent inhibition of human leukaemia cell line and human histolytic lymphoma cell line while was found to be lesser active against normal human kidney cells displaying safety for normal cells.
Conclusion: Study results show that root extracts of Rubia Cordifolia is promisingly cytotoxic and they might have antitumor activity against myeloid leukemia and Histolytic lymphoma. None of the fraction of the extract was found to be cytotoxic against the normal cell line (HEK293) in the given range of concentration. So, this plant extracts may have clinical and therapeutic proposition in the most life threaten disease like cancer and further studies are required to investigate this plant as source of antineoplastic agents